Cruz-Martin Lab

University of Colorado Denver

ANESTHESIOLOGY

Aurora · United States

NIH-funded
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NIH R01 · 2025

Functional heterogeneity of vasoactive intestinal peptide-expressing interneurons in the anterior cingulate cortex

PROJECT SUMMARY Cortical subregions are often implicated in a variety of behavioral functions, but it is not well understood how these areas encode such diverse information. The anterior cingulate cortex (ACC) is necessary for emotional processing and social cognition, but how it encodes stimuli relevant to both processes is unknown. The goal of this proposal is to understand the functional heterogeneity of ACC circuits, and how this impacts encoding of diverse stimuli and cognitive function. In Aim 1, we will determine the functional heterogeneity of ACC inhibitory circuits during social and anxiety-like behaviors. To monitor interneuron activity, we will first inject an adeno- associated…

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