NIH R01 · 2024
Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain Tissue
Abstract of the proposed research that shows the relevance to AD/ADRD Chronic pain and Alzheimer's disease and related dementias (AD/ADRD) are common in older age and emerging evidence links pain as a significant risk factor for subsequent cognitive decline and dementia. However, the up-to-10-year preclinical phase of AD/ADRD with no objective cognitive deficits significantly limits the study of pain’s potential impact on cognition, and once diagnosed, there are significant limitations assessing the multidimensional pain experience using verbal reports. Given the complexity of chronic pain in aging, there are likely a combination of mechanisms contributing to pain-cognitive decline…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.