NIH R01 · 2024
Regulation of the Brucella abortus general stress response
Project Summary/Abstract The goal of this research proposal is to advance molecular-level understanding of a conserved signal transduction system that influences the ability of Brucella abortus to survive chemical and physical stress conditions, and to colonize mammalian hosts. The general stress response (GSR) signaling system controls stress adaptation and chronic infection in a mammalian model of brucellosis. We are working to understand how B. abortus detects environmental signals via a set of HWE-family histidine kinases to influence infection. We have preliminary evidence that two sensor kinases coordinately control GSR activation and infection in B. abortus. We have further…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.