NIH R01 · 2024
The Role of lymphatic endothelium in the developing thymus
PROJECT SUMMARY/ABSTRACT Studies of the thymic microenvironment have focused largely on the central role of thymic epithelial cells (TECs) during development, disease and aging. However recent evidence suggests that the thymic vascular compartment also plays an active and complex role within the thymus beyond that of a simple conduit for hematopoietic cells. This role is particularly evident during the neonatal period when robust thymopoiesis is accompanied by a profound though transient phase of angiogenesis, followed by rapid maturation of TECs. This research proposal builds on the recent and novel finding that the vasculature of the neonatal thymus is in fact dominated by lymphatic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.