NIH R01 · 2024
Diagnostic validity and safety of high-gamma language mapping with intracranial EEG
To avoid post-operative language impairments after surgery for drug-resistant epilepsy, electrical cortical stimulation mapping (ESM) is widely relied upon to localize language cortex, but ESM often elicits after- discharges (ADs), seizures, involuntary movements, and pain, which can limit mapping and impact patient safety. Furthermore, ESM is time-consuming and usually produces all-or-none results, providing limited insight into the function of stimulated sites. Finally, up to 30% of patients can have language dysfunction after resections that are guided by ESM. These limitations have motivated an alternative mapping method based on task-related power changes in high-gamma frequencies…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.