NIH R01 · 2024
The Neutrophil Lineage in Inflammasomopathies
Abstract The study of cryopyrin associated periodic syndromes (CAPS) has shaped our view of innate immunity, and led to the clinical translation of therapies for CAPS and other NLRP3-dependent inflammatory diseases. Our preliminary in vivo genetic data now suggest that the assumed central role of monocytes and macrophages in CAPS may be overstated. Rather, the neutrophil lineage alone can drive lethal autoinflammation in CAPS neonatal mice, and this is indistinguishable from systemic NLRP3 activation. The molecular regulation of NLRP3 inflammasome activation is distinct in neutrophils compared to macrophages, so this research will study biochemical regulation of NLRP3 activation in mouse…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.