NIH R01 · 2024
Molecular genetic analysis of MEF2 function in Drosophila
Project Summary/Abstract. Members of the Myocyte enhancer factor-2 (MEF2) family of transcription factors play prominent roles in the differentiation of the musculature, and changes in MEF2 function are strongly associated with human disease mechanisms. Central to understanding the mechanistic basis of MEF2-dependent disease is an understanding of the normal function of this important factor. Research over many years has uncovered numerous cofactors that impact MEF2 function, however we still lack a full understanding of the global regulation of MEF2 function during muscle development, and of how that process goes awry in the diseased state. Our research uses the Drosophila model system,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.