NIH R01 · 2025
Project Summary: Type 1 diabetes results from impaired central and peripheral tolerance mechanisms. β-cell antigen-reactive T cells escape negative selection in the thymus and regulation/deletion in the periphery. While the role and therapeutic potential of professional antigen-presenting cells and regulatory T cells in maintaining peripheral tolerance in type 1 diabetes is known, non-professional antigen presenting stromal cells residing in lymph nodes remain understudied. For maintaining and therapeutically promoting peripheral tolerance to self-antigens such as type 1 diabetes-relevant ones, these stromal cells present unique advantages over other antigen-presenting cells due to their…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.