NIH R01 · 2025
Alcohol and gut-brain axis and the role of butyrate on neuroinflammation and pain sensitivity
ABSTRACT Chronic pain lasts for months or years which negatively impacts quality of life. Alcohol, an effective analgesic, is commonly used to self-medicate for pain, and strongest analgesia occurs for alcohol levels exceeding World Health Organization guidelines for low-risk drinking, which could explain alcohol misuse in those with persistent pain. The gut microbiota regulates many neurological disorders, including chronic pain. Both alcohol use disorder (AUD) and many pain disorders are associated with a disruption in microbiome composition and function (gut dysbiosis), neuroinflammation, neuronal damage, and behavioral alterations. Gut microbial- derived short-chain fatty acids (SCFA:…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.