NIH R01 · 2025
Mechanisms of age-related tauopathy
ABSTRACT In 2014, we proposed criteria for a new category of Alzheimer disease (AD) neuropathological change describing subjects with AD-type neurofibrillary tangles without significant amyloid-beta (Aβ) deposition. This autopsy designation, termed primary age-related tauopathy (PART), is the subject of increasing investigation, with studies suggesting that PART diverges in important ways from AD. There is a critical need to better understand what differentiates PART from other tauopathies and AD, which it mimics clinically and neuropathologically. We are assembling a large collection of brain tissues from aged individuals to enable histopathological, genetic and mechanistic molecular…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.