NIH R01 · 2024
Androgen Signaling in CaP with loss of MAP3K7 and CHD1
Prostate cancer is characterized by large genomic rearrangements and deletions. We show that the genes CHD1 and MAP3K7 are co-deleted in ERG translocation negative prostate cancer. To demonstrate a functional cooperativity we used a novel mouse prostate stem cell developmental model and showed that collaborative loss of CHD1 and MAP3K7 promotes an aggressive prostate cancer phenotype with altered lineage differentiation, abnormal secretory products, massive nuclear atypia, loss of E-cadherin and enrichment in neuronal and neuroendocrine markers. Profound alterations in AR expression were also observed. Using multiple human cell line models we also demonstrate that loss of CHD1 and MAP3K7…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.