NIH R01 · 2024
Optimization and chemical biology of novel antifungals to combat azole resistant mould infections
Project Summary. The filamentous fungi, or moulds, present a particularly daunting clinical challenge with high treatment failure rates and intrinsic and/or emerging multi-drug resistance. Currently, only 3 classes of antifungal drugs are utilized to treat the majority of human fungal infections. We aim to address this significant and growing human health problem by developing a nonspirocyclic piperidine series (NSP) series of small molecules with potent antifungal activity that can overcome mould specific antifungal drug resistance in the complex infection microenvironment. The NSP series was discovered using a high-throughput small molecule antifungal screen under low oxygen conditions…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.