NIH R01 · 2025
ATP-Dependent Chromatin Remodeling in Human Malignancy
Project Summary ATP-Dependent Chromatin Remodeling in Cancer Chromatin and epigenetic regulators have emerged as important contributors to human cancer. The subunits of the mSWI/SNF or BAF ATP-dependent chromatin remodeling complex are mutated in over 20% of human cancers. In addition, several other ATP-dependent remodelers make important contributions to the pathogenesis of specific cancers. These complexes often function as genetically dominant tumor suppressors, however the BAF complex also plays oncogenic roles in synovial sarcoma and squamous cell carcinoma. Despite their prevalent roles in human cancer their oncogenic mechanism(s) remain unclear and a detailed molecular understanding,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.