NIH R01 · 2024
The Role of FcRn in Echovirus Entry and Pathogenesis
PROJECT SUMMARY/ABSTRACT: The overarching goal of this application is to identify the role of the neonatal Fc receptor (FcRn) in echovirus entry and pathogenesis. We recently identified FcRn as a pan-echovirus receptor. We showed that gene editing of FcRn resulted in reduced echovirus infection of cells, and reciprocally, ectopic expression promoted infection in non-permissive cells. We also found that FcRn bound directly to echoviral particles and enhanced virus attachment to cells. Consistent with these findings, recombinant FcRn protein or monoclonal antibodies to FcRn blocked echovirus infection in multiple cell types. Finally, expression of the human homologue of FcRn rendered neonatal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.