NIH R01 · 2025
Regulation of Chlamydial Divisome Assembly
The obligate intracellular pathogen Chlamydia trachomatis is the leading bacterial cause of sexually transmitted infections. This coccoid, gram-negative bacterium does not encode several proteins essential for binary fission including FtsZ, the major regulator of binary fission in most bacteria, and we previously showed that Chlamydia divides by a polarized budding process. Our data indicate that chlamydial budding is driven by a novel hybrid division machinery that contains elements of the divisome (FtsK, PBP3) and elongasome (MreB, MreC, and PBP2) machinery defined in other bacterial systems. However, many questions regarding the mechanisms that regulate this polarized division process…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.