NIH R01 · 2024
Molecular mechanisms of bundled actin structure assembly by formins
PROJECT SUMMARY The goal of this research is to understand how formins shape the architecture and dynamics of the actin cytoskeleton. Formins are a uniquely versatile family of actin regulatory proteins that stimulate both filament nucleation and elongation. Actin filaments assembled by formins are incorporated into a diverse set of higher- order structures that support essential cellular functions, including migration, division, and transport. Mammals express 15 formin isoforms, each of which possesses unique actin assembly properties and plays a specific role in cells. Consistent with this specialization, mutations in individual formin genes are linked to a broad range of diseases and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.