NIH R01 · 2024
Keratinocyte-dependent regulation of innate immune responses in inflamed skin
SUMMARY Inflammation, dysregulated innate immune responses, and loss of barrier function underlie several skin conditions including psoriasis, atopic dermatitis, hidradenitis suppurativa, and pachyonychia congenita. Compelling evidence now shows that signals regulating inflammation and innate immunity are produced and secreted by stressed keratinocytes making up the skin epidermis. How the relevant signals are generated in keratinocytes, their cellular targets, and the pathways involved in ensuring proper regulation of inflammation and innate immunity in healthy skin tissue, and their dysregulation in disease, remain poorly understood. This multi-PI proposal takes advantage of the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.