NIH R01 · 2025
Imaging microglia in virally-suppressed HIV
PROJECT SUMMARY In spite of the benefits of antiretroviral therapy, the burden of central nervous system complications remains high among virally-suppressed people with human immunodeficiency virus (VS+PWH). Study of cognitive impairment across cohorts of VS+PWH often reveals subsets of VS+PWH with relatively marked, low performance in executive function (EF) that is now referred to as cognitive control (CC). This project aims to study regional proliferation of microglia, and the relationship to EF/CC in VS+PWH. Our focus on positron emission tomography (PET) imaging of microglia stems from our previous efforts. Our group validated use of [11C]DPA-713 (DPA) PET to localize a microglial…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.