NIH R01 · 2025
Contribution of AD genetic risk and microglial BIN1 to tauopathy
Summary/Abstract Late-onset idiopathic Alzheimer’s Disease (AD) is the most common cause of dementia and the sixth leading cause of death in the United States. While the pathology and disease progression of AD is well-documented, current effective therapies are limited. With the incidence of AD expected to climb over the next half century, it is critical to further investigate the molecular and cellular mechanisms underlying idiopathic AD. Genome-wide association studies have identified numerous noncoding genetic variants that are highly associated with AD, but the cell type specific function of these variants and how they confer AD risk remains unknown. The strongest noncoding risk loci…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.