Cotton Lab

Rehabilitation Institute of Chicago D/B/a Shirley Ryan Abilitylab

Chicago · United States

NIH-funded
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NIH R01 · 2025

Predictive Gait-Based Biomarkers for Fall Risk in Lower-Limb Prosthesis Users

ABSTRACT Falls are the second leading cause of unintentional death worldwide and lower limb prosthesis users (LLPUs) constitute an exceptionally high-risk group. Over half of LLPU fall annually with many falls resulting in injuries.1 Despite these alarming statistics, clinically accessible tools for predicting falls in LLPU are currently lacking. A comprehensive fall prevention research program should address barriers, such as population heterogeneity and specificity of measurements, and identify modifiable biomechanical risk factors across LLPUs subgroups using methods easily translatable into clinical use.4 Gait analysis to as a screening tool for falls has the potential to satisfy these…

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