Costa Lab

Oregon Health & Science University

OTHER BASIC SCIENCES

Portland · United States

NIH-funded
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NIH R01 · 2024

Neurocomputational mechanisms of explore-exploit decision making in prefrontal and motivational neural circuits

Project Summary The explore-exploit dilemma refers to the challenge of deciding when to forego choices with known consequences to explore new opportunities and learn more about them. Managing this trade-off is a fundamental component of behavioral flexibility. Excessive exploration or exploitation impedes learning and results in poor choices leading to undesired outcomes. Explore-exploit decision making is understudied in psychiatry despite its ecological validity and relevance in understanding disorders characterized by inflexible behaviors. One reason for this is we have not identified if the brain encodes information relevant for managing explore-exploit tradeoffs differently when…

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