NIH R01 · 2025
NEDD9 and Chromium(VI) Carcinogenesis
Cr(VI) compounds are carcinogenic to humans. The underlying mechanism remains unknown. Neural Precursor Cell Expressed Developmentally Down-regulated Protein 9 (NEDD9), a multi-domain scaffolding protein, is crucial for tumorigenesis. High expression of NEDD9 is correlated with advanced clinical stage of non-small cell lung carcinomas (NSCLC). Autophagy is a key regulator that maintains p62 at desired levels. Upregulation of p62 is associated with various carcinogenic processes. Our preliminary studies show that in Cr(VI)-transformed cells, NEDD9 is upregulated, and autophagy is impaired, resulting in the upregulation of p62, Nrf2, and Bcl-2. Knockdown of NEDD9 decreases p62 and Nrf2…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.