Coslett Lab

University of Pennsylvania

NEUROLOGY

Philadelphia · United States

NIH-funded
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NIH R01 · 2024

Electrical Field Guided TMS and Constraint Induced Language Therapy to TreatPost-Stroke Aphasia in the Subacute Stage

Project Summary Transcranial Magnetic Stimulation (TMS), sometimes in conjunction with Speech-Language Therapy, has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies. Several lines of evidence suggest that it is more effective when provided in the subacute stage after stroke but its efficacy in this setting has not been adequately assessed. We propose to study the effects of continuous Theta Burst Stimulation (a type of TMS) combined with a modified form of Constraint Induced Language Therapy (mCILT) in 63 subjects with subacute aphasia. Subjects will be randomized in a 2:1 ratio to cTBS with mCILT or sham cTBS with mCILT. After…

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