NIH R01 · 2024
Estrogenic modulation of neural circuits that control temperature
PROJECT SUMMARY Estrogen withdrawal at menopause is associated with a suite of metabolic, vascular, and neuroendocrine changes that impact health and quality of life. The most specific symptoms associated with menopause are vasomotor symptoms, which include hot flashes and night sweats. It is thought that vasomotor symptoms are caused by fluctuating estrogen levels at the time of the menopausal transition. However, it is unclear how these changes affect temperature regulation in the brain. Our preliminary data identify a thermoregulatory role for neurons that express estrogen receptor alpha (ERalpha) in the medial preoptic area (MPO) of the hypothalamus, a potent temperature sensor and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.