NIH R01 · 2024
Biomimetic intervention strategies for endogenous in utero repair of Spina Bifida
ABSTRACT Neural tube defects (NTDs), including spina bifida (SB), have a devastating impact on the health and development of infants and children, with economic, social, and physical demands or hardships placed on caregivers. SB affects approximately 2,500 live births per year in the United States, with environmental and genetic factors playing a role in its etiology. By combining bioengineering and placental-derived stem cell approaches, the CuRe (Cellular Therapy for In Utero Repair of Myelomeningocele) trial has recently advanced surgical effectiveness and improved clinical outcomes. However, in utero repair requiring fetal exposure at mid- pregnancy to reduce the ongoing damage of the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.