NIH R01 · 2025
The human-specific pathogen Neisseria gonorrhoeae (Ngo) causes the common sexually transmitted infection gonorrhea. Rapid evolution of drug resistance by Ngo has led to its identification as an urgent threat and emphasizes the need to identify an efficacious vaccine or more effective treatments. Our strategy to develop better therapeutics has focused on conserved outer membrane transport proteins that provide critical growth supporting functions during human infection. The outer membrane transport system (TbpA/B) that enables Ngo to employ human transferrin as an iron source is necessary for and produced during human infections. The highly conserved zinc transporters (TdfH and TdfJ) are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.