NIH R01 · 2025
The human-specific pathogen Neisseria gonorrhoeae (Ngo) causes the sexually transmitted infection gonorrhea. Ngo frequently causes infections localized to the urogenital tract in both males and females, though manifestations such as pelvic inflammatory disease, ectopic pregnancy and infertility can result from untreated infection. Rapid evolution of drug resistance by Ngo has led to its identification as an urgent threat and hastens the need to identify an efficacious vaccine. Our vaccine strategy targets conserved outer membrane transport proteins that provide critical growth-supporting functions during human infection. The outer membrane transport system (TbpA/B) that enables Ngo to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.