NIH R01 · 2025
PROJECT SUMMARY Computed tomography (CT) is an x-ray based medical imaging technique commonly used for non-invasive gastrointestinal tract (GIT) imaging. Iodine and barium based CT contrast agents are used in the clinic for GIT imaging, however, inflammatory bowel disease (IBD) imaging is challenging since iodinated and barium based CT agents are not specific for sites of inflammation. Cerium oxide nanoparticles (CeNP) produce strong x-ray attenuation due to cerium's k-edge at 40.6 keV, but have only recently begun to be explored for CT imaging. We hypothesized that the use of dextran as a coating material on cerium oxide nanoparticles would encourage accumulation in IBD inflammation sites…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.