NIH R01 · 2024
Molecular Mechanisms of Auditory Transduction
Project Summary The most fundamental event in the initiation of hearing is the conversion of sound into an electrical signal by the opening of ion channels in hair cells. We know that TMC1 and TMC2 are the pore-forming subunits of the mechanotransduction complex, we know the general tertiary structure of TMCs, and we know which transmembrane domains constitute the pore. But we now need to know specifically how the sound-evoked increase in tip-link tension leads to channel opening: how does PCDH15 in the tip link attach to TMC1, what moves in TMC1 to open the pore, and how does tension propagate through the TMC channel to cause that opening? In this project we will first identify the parts…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.