Cordoba-Chacon Lab

Research focus

NIH R01 · 2025

PPARgamma-regulated mechanisms in hepatocytes that promote NAFLD

PROJECT SUMMARY / ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease with a prevalence of 25% in the general population. NAFLD is strongly associated with type 2 diabetes, where it shows a prevalence up to 80%, and a strong progression to non-alcoholic steatohepatitis (NASH, and advance stage of NAFLD). To date, there are no FDA-approved pharmacological treatments for NAFLD. However, thiazolidinediones (TZD), which are effective anti-diabetogenic drugs, may be used to treat NAFLD/NASH. Specifically, TZD activate peroxisome proliferator-activated receptor gamma (PPARγ) in adipocytes, macrophages, and hepatic stellate cells (HSC), and they should…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.