NIH R01 · 2025
State-dependent control of nociception in opioid circuits
ABSTRACT │ The perception of pain does not scale linearly with peripheral nociception. This highly modifiable feature of pain is tuned by a range of contexts: internal emotional or interoceptive states, as well as expectations and beliefs involving future outcomes that might make pain worse or better. One form of pain modulation is placebo analgesia—an endogenous antinociception process in which perceived pain is reduced by a treatment that has no pharmacological effect but relies on expectations of pain-relief. While fMRI has provided a roadmap of distributed brain circuits involved in placebo analgesia, in particular associative cortical areas, the amygdala, and the ventrolateral…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.