NIH R01 · 2025
Project Summary The obesity epidemic continues to afflict populations globally. The literature is replete with observational studies purporting a role of the gut microbiome in body weight regulation. The main gap in the development of microbiome-targeted therapeutics to treat obesity is a deep understanding of the causal mechanisms by which microbes impact energy balance in humans. In a first of its kind study, we implemented a quantitative bioenergetics paradigm in which human energy balance was deeply and precisely phenotyped (energy intake, expenditure and fecal energy loss) during an inpatient randomized controlled crossover feeding study. We used diets that delivered minimal (Western…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.