NIH R01 · 2024
Signaling pathways regulating mechanoreflex sensitization in cardiovascular disease
PROJECT SUMMARY Hallmark features of many forms of cardiovascular disease include exercise intolerance and a high risk of suffering an adverse ischemic cardiovascular event such as cardiac fibrillation, myocardial infarction, or stroke during physical exertion. An exaggerated increase in sympathetic nervous system activity during exercise (i.e., sympathoexcitation) is a direct contributor to exercise intolerance and the risk of such adverse events. During exercise, mechanical forces associated with contracting skeletal muscles stimulate small diameter muscle sensory neurons (group III/IV muscle afferents) which plays an integral role in the activation of a reflex, the exercise pressor…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.