NIH R01 · 2025
The Impact of Chronic Alcohol Abuse on the Pathophysiology of Sepsis
Over 100,000 patients with alcohol use disorder develop sepsis annually in the United States. Patients with alcohol use disorder who develop sepsis are significantly more likely to die or have a complicated intensive care unit stay than septic patients without a history of alcohol use disorder. This proposal aims to understand why alcohol use disorder worsens outcomes in sepsis, as understanding this could lead to precision medicine approaches in this patient population. Using a model of chronic alcohol ingestion that does not result in detectable end organ damage followed by sepsis, we are able to identify possible mechanisms for why mortality is worse in alcohol/sepsis. While the majority…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.