NIH R01 · 2024
PROJECT SUMMARY Decades of research using laboratory mice and rats have revealed mechanisms of human development and disease. It is highly likely that rodents have provided critical supporting data for clinical trials of every pharmaceutical or therapeutic approach currently used to improve human health. There are, however, limitations to the utility of mice and rats to understand and model complex genetic problems (e.g. Alzheimer's, heart disease, and diabetes) due to the rare probability of inheriting desired alleles at four or more loci and the small litter size compared to offspring of other traditional model species. The cost, time, and number of animals needed to model complex genetic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.