NIH R01 · 2024
Mechanisms for initiation of food allergy early in life
PROJECT ABSTRACT Food allergy often starts early in life and can be life threatening. Early introduction of peanut consumption is recommended to reduce development of peanut allergy. However, in the LEAP study, 14% of children were not included because they were skin prick positive for peanut allergy at the start or because they developed reactions during oral peanut exposures. Peanut allergy is associated with loss-of-function mutations in skin barrier genes. In mechanistic studies, we demonstrated that neonatal mice with heterozygous skin barrier mutations developed food allergy by skin co-exposure to detergent, food allergen and a ubiquitous environmental allergen, Alternaria alternata…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.