NIH R01 · 2024
Impact of T cells on the CNS during aging and Alzheimer’s disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is a neurodegenerative disease that results in amyloid β plaque deposition, neurofibrillary tangle (NFT) formation, and life-altering cognitive defects. Many human genetic AD risk factors, including APOE, CLU, and TREM2, modulate neuroinflammation and/or the function of microglia, the central nervous system (CNS) resident innate immune cell. Deletion of all peripheral adaptive immune cells (i.e. CD4+ T cells, CD8+ T cells and B cells) or T cell depletion (i.e. CD4+T cells, CD8+T cells) increased cognitive abilities in amyloidosis and tauopathy models, respectively, and were associated with altered microglial function. Interestingly, aging,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.