NIH R01 · 2024
Novel mechanisms of posttranscriptional regulation by CsrA
Abstract (30 lines of text) The mechanisms by which global regulatory proteins operate on their RNA targets are complex and are still largely not understood; understanding these mechanisms is crucial for preventing or alleviating bacterial infections. As one of the major established global post-transcriptional regulator in bacteria, the CsrA RNA- binding protein hides a wealth of strategies for efficient stress-induced posttranscriptional regulation that are not well understood. The overarching goal of the proposed work is to characterize in vivo the molecular features that underlie novel CsrA-target interactions that we have recently uncovered as well as to decipher the biological…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.