NIH R01 · 2024
Gating and Regulation of Connexin Hemichannels
The vast majority of the 20 human connexin isoforms have been associated with pathological dysfunctions, suggesting an essential physiological role for these proteins in human health. Although connexin channels are permeable to both atomic ions and small metabolites, they are highly selective to different molecules, which likely determines their distinct biological functions. They are also regulated by various stimuli, including Ca2+, voltage, and pH. Our understanding, however, of the molecular mechanisms underlying permeation and gating is extremely superficial, especially when compared with other classical ion channels. Recently, we made the surprising discovery that connexin…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.