NIH R01 · 2024
Anti-inflammatory signals and neurodegeneration
Abstract Neuroimmune signals regulate neuronal function and survival. We have obtained multiple pieces of evidence indicating that activation of the heterodimeric interleukin-13 receptor alpha 1/interleukin-4 receptor alpha (IL- 13Rα1/IL-4Rα) affects the viability of midbrain dopaminergic (DA) neurons. We found that in the brain, IL- 13Rα1/IL-4Rα is preferentially expressed on the neurons of the substantia nigra pars compacta (SNc) that are lost in Parkinson’s disease (PD). We also showed that interleukin 13 (IL-13), produced during neuroinflammation by microglia and neurons, can modulate the activity of dopaminergic cells and increase their susceptibility to oxidative damage. Thus, having…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.