NIH R01 · 2025
Role of BK channels in alcohol-induced dysmyelination
SUMMARY Myelination is essential to efficient action potential propagation and neuron survival. The bulk of myelination occurs during development, but new myelin sheaths continue to be added throughout adulthood, especially in white matter tracts. Chronic alcohol exposure alters the expression of myelin genes/proteins and reduces the volume and microstructural integrity of white matter tracts both in humans and in animal models. However, the molecular and cellular mechanisms driving these effects are poorly understood. The present project seeks to address the structural and functional correlates of myelin protein changes in a mouse model of alcohol use disorder that combines voluntary…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.