NIH R01 · 2024
Non-small cell lung cancers (NSCLC) are aggressive tumors that are a major cause of morbidity and mortality in the United States. In the past decade, the introduction of systemic therapies such as receptor tyrosine kinase targeted inhibitors and immune checkpoint inhibitors have significantly improved patient outcomes. However, therapeutic resistance to these therapies frequently develops and is characterized by parallel signaling through other co-expressed receptor glycoproteins. We have therefore investigated the feasibility of disrupting asparagine (N) linked glycosylation, a co- and post-translational protein modification, as a strategy to block both primary and bypass glycoprotein…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.