NIH R01 · 2024
Acetylcholine determines dopamine's role in learning versus moving
Project Summary The neuromodulator dopamine is implicated in most neuropsychiatric disorders, and also several movement disorders. A wealth of data has implicated dopamine release in the striatum -the input structure of the basal ganglia- in both learning and motor control. Therefore, a major outstanding question for the field is understanding how dopamine can satisfy these dual functions within the same brain area, using the same neural machinery. For the most part, previous studies have either focused on movement or learning in separate experiments. The proposed work has two main goals: (1) to relate dopamine release in the striatum to both learning and motor control on single trials in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.