NIH R01 · 2024
Mechanisms of KSHV posttranscriptional gene regulation
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi’s sarcoma and lymphoproliferative diseases primarily in immunocompromised patients. Like all herpesviruses, KSHV uses the host gene expression machinery to carefully control the timing and abundance of viral mRNAs in its latent and lytic phases. While emphasis has been placed on transcriptional control, recent reports suggest two distinct interactions between KSHV and host RNA quality control (QC) pathways that degrade nuclear transcripts. The goal of this proposal is to define the molecular mechanisms at the interface of host nuclear RNA QC pathways and KSHV gene expression. The aims will define…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.