NIH R01 · 2024
Disease Mechanisms of Prenatal and Pediatric Acquired Hydrocephalus
Abstract Infections, both bacterial and viral, have been linked to pediatric hydrocephalus and can impact the nascent brain’s developmental programs. In fetal development, stem cells line the ventricles and provide neurons and glia required for brain development; ventricle-contacting stem cells also generate a protective epithelial monolayer of ependymal cells. As ependymal cells form a barrier wall along the ventricles, the remaining stem cells are relegated to the subependymal zone and retain only a thin apical process in contact with the cerebral spinal fluid. This unique arrangement characterizes the stem cell niche along the lateral walls of the lateral ventricle and supports continued…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.