NIH R01 · 2024
Mechanisms and Regulation of Brain Iron Uptake
PROJECT SUMMARY Iron delivery to the brain is essential for multiple neurological processes such as myelination, neurotransmitter synthesis and, as it is for all organs, for the utilization of oxygen for energy production. Previously, we introduced and established the concept that brain iron uptake is regulated at the level of the endothelial cells of the blood-brain barrier (BBB), which is contrary to the widely held concept that the BBB endothelial cells serve as a simple conduit for the delivery of transferrin. We also identified H-ferritin, classically considered an intracellular iron storage protein, as a significant iron delivery protein for the brain. Both of these new concepts start…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.