NIH R01 · 2024
Integrated omics analysis of clonal hematopoiesis and cardiovascular disease risk in TOPMed
PROJECT SUMMARY Clonal hematopoiesis of indeterminate potential (CHIP) involves the gain of somatic mutations that confer a selective advantage to hematopoietic stem cells and lead to the expansion of a clonal population of blood cells. CHIP is common in older individuals and is associated with increased risk of blood cancers and atherosclerotic cardiovascular disease (ASCVD). Genes commonly mutated in CHIP include known regulators of DNA methylation (DNAm) and RNA splicing. In this application, we propose to take advantage of a novel omics data resource being generated by the TOPMed program to investigate the roles of DNAm, gene expression, and differential splicing as mechanisms…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.