NIH R01 · 2025
Functions of Metabotropic Glutamate Receptor Subtypes
Emerging, preclinical, clinical, and human genetic studies raise the exciting possibility that selective activators of the mGlu1 subtype of metabotropic glutamate (mGlu) receptor have potential utility as a novel approach for treatment for schizophrenia. However, until recently, tools were not available to allow studies of the functional roles of mGlu1 in specific brain circuits. We have now developed highly selective mGlu1 positive allosteric modulators (PAMs), along with genetic mouse lines that allow selective deletion of mGlu1 in specific neuronal populations. This provides an unprecedented opportunity to establish the roles of mGlu1 in specific brain circuits that are disrupted in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.