NIH R01 · 2025
Calprotectin and Antibiotic Activities at the Infection Interface
Calprotectin is the most abundant protein in neutrophils. Our surprising discovery that calprotectin can bind and hydrolyze multiple β-lactam antibiotics forms the basis of this proposal. In particular, calprotectin hydrolyzes and inactivates the penicillin sub-class that includes ampicillin, amoxicillin and oxacillin, which are among our most important and most widely used antibiotics. The identification of calprotectin as the first known host protein with β-lactamase activity has major implications for the treatment of infection. Indeed, our preliminary data demonstrate that human neutrophils hydrolyze β-lactam antibiotics in tissue culture and that oxacillin treatment is more effective…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.