NIH R01 · 2025
Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models Abstract Alzheimer's disease (AD) is a prevalent age-related neurodegenerative disorder. While early-onset AD is driven by well-characterized genes, the mechanistic links between aging and late-onset AD remain elusive. Human genetic studies have revealed numerous risk alleles that modulate AD susceptibility, but their complex interactions are challenging to study using current tools. We propose to develop Combo-Seq/Tag, a powerful toolkit combining precisely installing multiple risk alleles (Combo-Seq) with a multiplex protein tagging tool (Combo-Tag) for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.